Table 9.
Number of GJIC protein Cx32 spots in the liver of F344 rats from a 2-year feeding study of p,p′-DDT
| Dose (ppm) | Sex | No. of Cx32 spots (mean ± SD) at weeks | |||||||
|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||
| 26 | 52 | 78 | 104 | ||||||
| 0 | M | 7.07 ± 0.94 | (6) | 6.49 ± 1.46 | (6) | 3.05 ± 0.19 | (6) | 3.11 ± 1.15 | (5) |
| F | 6.08 ± 0.97 | (6) | 6.48 ± 0.66 | (6) | 3.26 ± 0.74 | (6) | 3.73 ± 0.23 | (5) | |
| 5 | M | 6.87 ± 0.54 | (6) | 6.95 ± 0.88 | (6) | 2.51 ± 0.50* | (6) | 2.13 ± 0.37 | (5) |
| F | 5.67 ± 0.93 | (6) | 5.51 ± 1.62 | (6) | 2.90 ± 0.41 | (6) | 3.59 ± 0.42 | (6) | |
| 50 | M | 5.53 ± 0.83* | (6) | 6.28 ± 1.88 | (6) | 2.47 ± 0.44* | (6) | 2.13 ± 0.35 | (4) |
| F | 4.80 ± 0.86 | (6) | 4.20 ± 0.56** | (6) | 1.76 ± 0.69* | (6) | 2.65 ± 0.33** | (6) | |
| 500 | M | 5.39 ± 1.30* | (6) | 4.64 ± 0.91 | (6) | 1.14 ± 0.22** | (6) | 1.52 ± 0.28* | (6) |
| F | 4.20 ± 1.41* | (6) | 3.28 ± 0.72** | (6) | 1.03 ± 0.16** | (6) | 1.75 ± 0.47** | (4) | |
(n): Number of animals examined.
*, **
Significantly different from control at p < 0.05 and p < 0.01, respectively (Dunnett’s multiple comparison test).