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. Author manuscript; available in PMC: 2016 Sep 3.
Published in final edited form as: Nature. 2016 Feb 24;531(7592):110–113. doi: 10.1038/nature16967

Extended Data Fig. 7. Increased mutant Kras allelic content leads to glucose metabolism reprogramming in lung tumours in vivo.

Extended Data Fig. 7.

a-i, Control (no Cre) and tumour bearing KrasG12D/+;p53Fx/Fx mice were infused with 13C-glucose 12 (early group) or 16 weeks (late group) after adenoviral-Cre treatment and individual lung tumours (Early, n=16 and Late, n=12) or control lung (Normal, n=3) collected for LC-MS analysis (3 technical replicates/sample). Selected 13C-glucose-derived metabolites shown, calculated as a percentage of the total metabolite pool. Mean abundance per cohort ±s.e.m. shown. ***P<0.001, *P<0.05 (two-way ANOVA).