. Author manuscript; available in PMC: 2016 Mar 7.

Published in final edited form as: N Engl J Med. 2015 Jul 2;373(1):48–59. doi: 10.1056/NEJMoa1411481

Table 3.

Severity of Pain, According to Likert Score.^*

Variable	European Union Trial		U.S. Trial
	Afamelanotide	Placebo	Afamelanotide	Placebo
Days recorded in diary — no.	9742	9601	8055	7368
Pain level — no. of days (% of recorded days)
No pain, Likert score of 0	8914 (92)^†	8463 (88)	7156 (89)^†	6245 (85)
Mild pain, Likert score of 1–3	687 (7)	777 (8)	753 (9)	840 (11)
Moderate pain, Likert score of 4–6	124 (1)	298 (3)	127 (2)	239 (3)
Severe pain, Likert score of 7–10	17 (<1)	63 (<1)	19 (<1)	44 (<1)

The difference in the distribution of pain scores between study-drug groups was analyzed by means of the chi-square test.

^†

P<0.001 for the comparison with placebo.