Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Selectivity profile of BrSAH across a panel of methyltransferases
| MTase | Ki (μM)* |
|---|---|
| DOT1L | 0.038 ± 0.002 |
| NNMT | 0.75 ± 0.05 |
| DNMT1 | 0.95 ± 0.1 |
| PRMT3 | 1.15 ± 0.1 |
| PRMT5 | 1.15 ± 0.15 |
| MLL | No inhibition |
| PRC2 | No inhibition |
| G9a | No inhibition |
| EHMT1 | No inhibition |
| SUV39H2 | No inhibition |
| SETD7 | No inhibition |
| SETD8 | No inhibition |
IC50 values were determined at cofactor concentration equal to Km value for SAM for each enzyme, and used to calculate Ki values as described by Cer et al.29
