Table 4.
Comparison of clinical and therapeutic features between patients who obtained and did not obtain effective salvage therapy after potential salvage therapy
| Total 145 | EST YES n=36 (%) | EST NO n=109 (%) | p Univariate | |
|---|---|---|---|---|
| Gender | 0.3 | |||
| Male | 91 | 20 (22.0) | 71 (78.0) | |
| Female | 54 | 16 (29.6) | 38 (70.4) | |
| Age | 0.9 | |||
| Median (range) | 59 (31-81) | 61.5 (31-81) | 59 (37-78) | |
| Mean ± SD | 58.4 ± 10.7 | 58.3 ± 14.2 | 58.4 ± 9.4 | |
| Simultaneous diagnosis | 0.6 | |||
| No | 119 | 31 (26.1) | 88 (73.9) | |
| Yes | 26 | 5 (19.2) | 21 (80.8) | |
| Disease-free interval < 12 months | 0.7 | |||
| No | 71 | 19 (26.8) | 52 (73.2) | |
| Yes | 74 | 17 (23.0) | 57 (77.0) | |
| Disease-free interval [months] | 0.7 | |||
| Median (range) | 10 (0-151) | 13 (0-128) | 9 (0-151) | |
| Mean ± SD | 17.4 ± 23.3 | 18.6 ± 24.5 | 17 ± 22 | |
| PRIMARY TUMOR | ||||
| Primary | 0.5 | |||
| Colon | 99 | 23 (23.2) | 76 (76.8) | |
| Rectum | 46 | 13 (28.3) | 33 (71.7) | |
| T (n=138) | 0.8 | |||
| 1 | 4 | 1 (25.0) | 3 (75.0) | |
| 2 | 12 | 2 (16.7) | 10 (83.3) | |
| 3 | 116 | 31 (26.7) | 85 (73.3) | |
| 4 | 6 | 1 (16.7) | 5 (83.3) | |
| Differentiation (n=135) | 0.9 | |||
| Well | 3 | 1 (33.3) | 2 (66.7) | |
| Moderately | 122 | 31 (25.4) | 91 (74.6) | |
| Poorly | 10 | 2 (20.0) | 8 (80.0) | |
| LVI (n=107) | 0.8 | |||
| No | 70 | 18 (25.7) | 52 (74.3) | |
| Yes | 37 | 8 (21.6) | 29 (78.4) | |
| PNI (n=89) | 1 | |||
| No | 69 | 19 (27.5) | 50 (72.5) | |
| Yes | 20 | 5 (25.0) | 15 (75.0) | |
| Lymph nodes (primary) | 0.03 | |||
| Negative | 66 | 22 (33.3) | 44 (66.7) | |
| Positive | 79 | 14 (17.7) | 65 (82.3) | |
| Total number of lymph nodes resected (n=122) | 0.6 | |||
| Median (range) | 12 (0-52) | 10 (0-39) | 12 (0-52) | |
| Mean ± SD | 14.5 ± 10.5 | 13.7 ± 10.4 | 14.7 ± 10.6 | |
| Total positive number (n=138) | 0.4 | |||
| Median (range) | 1 (0-14) | 0 (0-12) | 1 (0-14) | |
| Mean ± SD | 2 ± 2.9 | 1.7 ± 3.3 | 2.1 ± 2.7 | |
| LIVER METASTASES | ||||
| Extrahepatic disease | 0.8 | |||
| No | 106 | 27 (25.5) | 79 (74.5) | |
| Yes | 39 | 9 (23.1) | 30 (76.9) | |
| Major Resection | 1 | |||
| No | 57 | 14 (24.6) | 43 (75.4) | |
| Yes | 88 | 22 (25.0) | 66 (75.0) | |
| Margin | 0.3 | |||
| Negative | 133 | 35 (26.3) | 98 (73.7) | |
| Positive | 12 | 1 (8.3) | 11 (91.7) | |
| CEA > 200 ng/mL (n=134) | 0.7 | |||
| No | 125 | 31 (24.8) | 94 (75.2) | |
| Yes | 9 | 1 (111) | 8 (88.9) | |
| Preoperative CEA ng/mL (n=134) | 0.6 | |||
| Median (range) | 10.2 (0.5-16348) | 10.2 (0.5-12325) | 10.3 (0.5-16348) | |
| Mean ± SD | 275 ± 1774 | 403 ± 2176 | 235 ± 1639 | |
| >1 tumor | 0.03 | |||
| No | 57 | 20 (35.1) | 37 (64.9) | |
| Yes | 88 | 16 (18.2) | 72 (81.8) | |
| Number of tumors | 0.1 | |||
| Median (range) | 2 (1-11) | 1 (1-11) | 2 (1-11) | |
| Mean ± SD | 2.8 ± 2.5 | 2.3 ± 2.1 | 2.9 ± 2.6 | |
| Tumor size > 5cm | 0.5 | |||
| No | 109 | 29 (26.6) | 80 (73.4) | |
| Yes | 36 | 7 (19.4) | 29 (80.6) | |
| Tumor size (largest) [cm] | 0.1 | |||
| Median (range) | 3.5 (0.6-14.5) | 3.1 (1.2-9.5) | 4 (0.6-14.5) | |
| Mean ± SD | 4.3 ± 2.7 | 3.7 ± 2.2 | 4.4 ± 2.9 | |
| Clinical risk score | 0.03 | |||
| 0 | 13 | 7 (53.8) | 6 (46.2) | |
| 1 | 32 | 11 (34.4) | 21 (65.6) | |
| 2 | 54 | 11 (20.4) | 43 (79.6) | |
| 3 | 38 | 6 (15.8) | 32 (84.2) | |
| 4 | 8 | 1 (12.5) | 7 (87.5) | |
| 5 | 0 | 0 | 0 | |
| Clinical risk score | 0.09 | |||
| Low | 99 | 29 (29.3) | 70 (70.7) | |
| High | 46 | 7 (15.2) | 39 (84.8) | |
| Neoadjuvant chemotherapy (n=144) | 0.7 | |||
| No | 100 | 24 (24.0) | 76 (76.0) | |
| Yes | 44 | 12 (27.3) | 32 (72.7) | |
| Adjuvant chemotherapy (n=140) | 0.8 | |||
| No | 17 | 3 (17.6) | 14 (82.4) | |
| Yes | 123 | 31 (25.2) | 92 (74.8) | |
| HAIP chemotherapy (n=144) | 0.8 | |||
| No | 102 | 25 (24.5) | 77 (75.5) | |
| Yes | 42 | 11(26.2) | 31 (73.8) | |
| Pattern of first recurrence | 0.8 | |||
| Liver only recurrence | 44 | 10 (22.7) | 34 (77.3) | |
| Lung only recurrence | 64 | 18 (28.1) | 46 (71.9) | |
| Other single sites only recurrence | 26 | 6 (23.1) | 20 (76.9) | |
| Multiple sites recurrence | 11 | 2 (18.2) | 9 (81.8) | |
| Number of tumors after recurrence | 0.78 | |||
| Solitary | 85 | 26 (30.6) | 59 (69.4) | |
| Multiple | 60 | 10 (16.7) | 50 (83.3) | |
| Type of resection after 1st recurrence (n=141) | 0.026 | |||
| R0 resection | 121 | 34 (28.1) | 87 (71.9) | |
| R1 resection | 20 | 1 (5.0) | 19 (95.0) | |
EST=effective salvage therapy, SD=standard deviation, LVI=lymphovascular invasion, PNI=perineural invasion, CEA=carcinoembryonic antigen, HAIP=hepatic arterial infusion pump.