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. 2016 Mar 2;12:339–350. doi: 10.2147/TCRM.S85099

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© 2016 Prosperini and Pontecorvo. This work is published and licensed by Dove Medical Press Limited

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Proposed treatment algorithm for treating R-MS with DMF.

Notes: ^aConsider pregnancy desire; ^bconsider anti-VZV serological status, comorbidities, and concomitant non-MS treatments (eg, cardiac illnesses, antihypertensive drugs); cconsider anti-JCV serological status; ^dconsider anti-VZV serological status, latent tuberculosis, and HPV screening. Please note that this algorithm, though based on currently available literature data, represents the authors’ opinion only.

Abbreviations: R-MS, relapsing multiple sclerosis; DMF, dimethyl fumarate; VZV, varicella zoster virus; JCV, John Cunningham virus; HPV, human papillomavirus; DMTs, disease-modifying treatments.