Table 3. Candidate gender-independent CGI-markers for Chronic Graft Injury in kidney transplant patients.

Microarray analysis using protein Ab arrays (Clontech-500) with pooled serum samples from kidney transplantation patients and controls was performed, as described in Material and Methods. Candidate CGI-markers were identified in CGI vs. Rest comparison (4-classes: NK, SF, AR, and CGI) using Comparative Marker Selection (Gene Pattern). Final selection was made using rank, score, feature P, and fold change.

Rank	Upregulated in	Feature	Description	Score	Feature P	Fold Change	CGI Mean	CGI Std	Rest Mean	Rest Std
1	Rest	O14920	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	-3.623	0.008	0.002	0.012	1.276	1.229	0.090
2	Rest	Q96NG9	syntaxin binding protein 5 (tomosyn)	-3.574	0.006	0.001	0.009	1.267	0.141	0.007
3	Rest	Q14186	transcription factor Dp-1	-3.479	0.028	0.017	0.037	1.759	0.265	0.051
4	Rest	P28482	mitogen-activated protein kinase 1	-3.382	0.006	0.001	0.009	1.908	0.181	0.071
5	Rest	P09874	ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)	-3.269	0.050	0.036	0.062	2.036	0.232	0.067
6	Rest	Q09028	retinoblastoma binding protein 4	-3.175	0.010	0.004	0.015	1.653	0.101	0.015
8	Rest	O95644	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1	-2.963	0.010	0.004	0.015	2.105	0.068	0.025
10	Rest	Q9NQX3	gephyrin	-2.933	0.018	0.009	0.025	1.255	0.965	0.072
12	Rest	P42679	megakaryocyte-associated tyrosine kinase	-2.746	0.036	0.024	0.046	1.738	0.171	0.046
13	Rest	Q07820	myeloid cell leukemia sequence 1 (BCL2-related)	-2.513	0.028	0.017	0.037	1.911	0.110	0.038