Table 4. Candidate gender-independent common AR-CGI-markers for Acute Rejection and Chronic Graft Injury in kidney transplant patients.

Microarray analysis using protein Ab arrays (Clontech-500) with pooled serum samples from kidney transplantation patients and controls was performed, as described in Material and Methods. Candidate AR-CGI-markers were identified in AR-CGI vs. Rest comparison (3-classes: NK, SF, AR-CGI) using Comparative Marker Selection (Gene Pattern). Final selection was made using rank, score, feature P, and fold change.

Rank	Upreulated in	Feature	Description	Score	Feature P	FDR (BH)	Fold Change	AR-CGI Mean	AR-CGI Std	Rest Mean	Rest Std
1	Rest	P28482	mitogen-activated protein kinase 1	-3.870	0.004	0.260	1.817	0.216	0.062	0.393	0.113
2	Rest	P09874	ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)	-3.527	0.004	0.260	2.128	0.263	0.090	0.560	0.220
3	Rest	P13624	signal recognition particle 54kDa	-3.472	0.008	0.272	1.565	0.099	0.027	0.154	0.036
4	Rest	Q14186	transcription factor Dp-1	-3.199	0.004	0.260	1.747	0.302	0.075	0.529	0.185
5	Rest	P49918	cyclin-dependent kinase inhibitor 1C (p57, Kip2)	-3.107	0.002	0.238	1.842	0.088	0.019	0.162	0.065
6	Rest	O14490	dynamin 1-like	-3.084	0.002	0.238	1.957	0.050	0.021	0.099	0.039
10	Rest	P24864	cyclin E1	-2.879	0.008	0.272	1.729	0.429	0.048	0.741	0.303
11	Rest	P42679	megakaryocyte-associated tyrosine kinase	-2.868	0.002	0.238	1.832	0.188	0.045	0.343	0.147
14	Rest	Q13691	v-ablAbelsonmurineleukemia viral oncogenehomolog 1	-2.678	0.006	0.260	1.649	0.095	0.020	0.156	0.062
15	Rest	O95644	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1	-2.483	0.006	0.260	1.940	0.084	0.028	0.163	0.086