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. Author manuscript; available in PMC: 2016 Mar 7.
Published in final edited form as: J Med Virol. 2015 May 6;87(10):1777–1787. doi: 10.1002/jmv.24238

TABLE II.

Sensitivity and Specificity Comparing Pathologic Diagnosis to HPV DNA Detected Within the External Genital Lesion

Sensitivity (%) 95%CI Specificity (%) 95%CI
Pathologist #1 (n = 334)
 Any HPV-related external genital lesion vs. any HPVa 48.6 42.9–54.4 70.0 55.8–84.2
 Condyloma vs. HPV 6/11b 46.6 40.1–53.0 64.7 55.4–74.0
 Penile intraepithelial neoplasia I–III vs. HPV 16/18c 36.8 15.2–58.5 98.7 97.5–100
 Penile intraepithelial neoplasia I–III vs. HR-HPVd 18.8 7.7–29.8 99.3 98.3–100
 Condyloma vs. LR-HPVe 46.1 40.3–51.9 73.1 61.0–85.1
Pathologist #3 (n = 156)
 Any HPV-related external genital lesion vs. any HPVa 44.9 36.6–53.2 77.8 58.6–97.0
 Condyloma vs. HPV 6/11b 43.6 34.4–52.9 71.7 58.7–84.8
 Penile intraepithelial neoplasia I–III vs. HPV 16/18c 20.0 00.0–44.8 98.0 95.6–100
 Penile intraepithelial neoplasia I–III vs. HR-HPVd 8.7 0–20.2 97.7 95.2–100
 Condyloma vs. LR-HPVe 42.5 34.2–50.9 81.8 65.7–97.9
a

All pathological diagnoses thought to be HPV-related (condyloma, penile intraepithelial neoplasia I, and penile intraepithelial neoplasia II/ III) and HPV genotyping results that included the presence of at least one of the 28 HPV genotypes included in the assay.

b

All pathological diagnoses thought to be HPV 6/11-related (condyloma) and HPV results that included either HPV 6 or 11, or both.

c

All pathological diagnoses thought to be HPV 16/18-related (penile intraepithelial neoplasia I, and penile intraepithelial neoplasia II/III) and HPV results that included either HPV 16 or 18, or both.

d

All pathological diagnoses thought to be related to HR-HPV infection (penile intraepithelial neoplasia I and penile intraepithelial neoplasia II/III) and HPV results that included the presence of at least one of the HR-HPV genotypes included in the assay.

e

All pathological diagnoses thought to be related to LR-HPV infections (condyloma) and HPV results that included the presence of at least one of the LR-HPV genotypes included in the assay.