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. Author manuscript; available in PMC: 2016 Mar 7.
Published in final edited form as: J Med Virol. 2015 May 6;87(10):1777–1787. doi: 10.1002/jmv.24238

TABLE III.

Sensitivity and Specificity Comparing HPV DNA Detected Within the External Genital Lesion to Pathologic Diagnosis

Sensitivity (%) 95%CI Specificity (%) 95%CI
Pathologist #1 (n = 334)
 Any HPV vs. any HPV-related external genital lesiona 92.3 88.1–96.5 15.6 10.3–21.0
 HPV 6/11 vs. condylomab 75.0 67.9–82.1 34.7 28.0–41.5
 HPV 16/18 vs. Penile intraepithelial neoplasia I–IIIc 63.6 35.2–92.1 96.3 94.2–98.4
 HR-HPV vs. Penile intraepithelial neoplasia I–IIId 81.8 59.0–100 87.9 84.4–91.5
 LR-HPV vs. condylomae 90.3 85.4–95.1 20.0 14.3–25.7
Pathologist #3 (n = 156)
 Any HPV vs. any HPV-related external genital lesiona 93.9 88.2–99.7 15.6 8.1–23.0
 HPV 6/11 vs. condylomab 78.7 68.4–89.0 34.7 25.2–44.3
 HPV 16/18 vs. Penile intraepithelial neoplasia I–IIIc 40.0 0.0–82.9 94.7 91.1–98.3
 HR-HPV vs. Penile intraepithelial neoplasia I–IIId 40.0 0.0–82.9 86.1 80.6–91.6
 LR-HPV vs. condylomae 93.4 87.2–99.7 19.0 11.1–26.8
a

All pathological diagnoses thought to be HPV-related (condyloma, penile intraepithelial neoplasia I, and penile intraepithelial neoplasia II/ III) and HPV genotyping results that included the presence of at least one of the 28 HPV genotypes included in the assay.

b

All pathological diagnoses thought to be HPV 6/11-related (condyloma) and HPV results that included either HPV 6 or 11, or both.

c

All pathological diagnoses thought to be HPV 16/18-related (penile intraepithelial neoplasia I, and penile intraepithelial neoplasia II/III) and HPV results that included either HPV 16 or 18, or both.

d

All pathological diagnoses thought to be related to HR-HPV infection (penile intraepithelial neoplasia I and penile intraepithelial neoplasia II/III) and HPV results that included the presence of at least one of the HR-HPV genotypes included in the assay.

e

All pathological diagnoses thought to be related to LR-HPV infections (condyloma) and HPV results that included the presence of at least one of the LR-HPV genotypes included in the assay.