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. 2016 Mar 15;10(2):166–176. doi: 10.5009/gnl15226

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Copyright © 2016 by The Korean Society of Gastroenterology, the Korean Society of Gastrointestinal Endoscopy, the Korean Society of Neurogastroenterology and Motility, Korean College of Helicobacter and Upper Gastrointestinal Research, Korean Association the Study of Intestinal Diseases, the Korean Association for the Study of the Liver, Korean Pancreatobiliary Association, and Korean Society of Gastrointestinal Cancer.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 4 — Mouse liver development at embryonic day 10. Foregut endoderm (FG) differentiates into hepatoblasts that are positive for immunohistochemical staining of cytokeratin (red). Cytokeratin+ hepatoblasts invade the surrounding septum transversum mesenchyme (STM) and form liver buds. The STM expresses mesothelial cell markers, such as activated leukocyte cell adhesion molecule (A, green) and Wilms tumor 1 homolog (WT1) (B). WT1+ mesenchymal cells also differentiate into epicardial cells of the developing heart (H). Scale bar, 20 μm.