Table 3.

Simplified Diagnostic Scoring System of the International Autoimmune Hepatitis Group

Category	Scoring elements	Results	Points
Autoantibodies	ANA or SMA	1:40 by IIF	+1
	ANA or SMA	≥1:80 by IIF	+2
	Anti-LKM1 (alternative to ANA and SMA)	≥1:40 by IIF	+2
	Anti-SLA (alternative to ANA, SMA and LKM1)	Positive	+2
Immunoglobulins	Immunoglobulin G level	>ULN	+1
		>1.1 times ULN	+2
Histological findings	Interface hepatitis	Compatible features	+1
		Typical features	+2
Viral markers	IgM anti-HAV, HBsAg, HBV DNA, HCV RNA	No viral markers	+2
		Probable diagnosis	≥6
		Definite diagnosis	≥7

ANA, antinuclear antibodies; SMA, smooth muscle antibodies; anti-LKM1, antibodies to liver kidney microsome type 1; SLA, soluble liver antigen; IIF, indirect immunofluorescence; ULN, upper limit of the normal range; IgM, immunoglobulin M; HAV, hepatitis A virus; HBsAg, hepatitis B surface antigen; HBV, hepatitis B virus; DNA, deoxyribonucleic acid; HCV, hepatitis C virus; RNA, ribonucleic acid.

Adapted from Hennes EM, et al. Hepatology 2008;48:169–176, with the permission of John Wiley & Sons, Inc. and the American Association for the Study of Liver Disease.²⁰