Table 3.
Univariate and Multivariate Cox Regression Analysis of the Risk Factors for Metachronous Gastric Neoplasm
| Variable | No. | No. of MGN (%) | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|---|---|
|
|
|
|||||
| HR (95% CI) | p-value | HR (95% CI) | p-value | |||
| Sex | ||||||
| Female | 74 | 3 (4.1) | 1 | - | ||
| Male | 183 | 16 (8.7) | 1.99 (0.58–6.88) | 0.275 | - | - |
| Age, yr | ||||||
| <65 | 99 | 11 (7.9) | 1 | 1 | ||
| ≥65 | 158 | 8 (6.8) | 1.29 (0.52–3.22) | 0.589 | 1.22 (0.45–3.31) | 0.699 |
| Family history of gastric cancer | ||||||
| No | 199 | 12 (6.0) | 1 | 1 | ||
| Yes | 50 | 6 (12.0) | 1.58 (0.59–4.24) | 0.364 | 3.52 (1.09–11.40) | 0.036* |
| Smoking status | ||||||
| Never | 102 | 7 (6.9) | 1 | - | ||
| Past | 113 | 7 (6.2) | 0.84 (0.29–2.40) | 0.745 | - | - |
| Current | 42 | 5 (11.9) | 1.90 (0.59–6.14) | 0.284 | - | - |
| H. pylori infection status | ||||||
| Never | 30 | 3 (10.0) | 1 | 1 | ||
| Past | 69 | 3 (4.3) | 0.51 (0.10–2.54) | 0.413 | 0.63 (0.10–3.86) | 0.613 |
| Current | 158 | 13 (8.2) | 0.95 (0.27–3.33) | 0.930 | 1.33 (0.27–6.45) | 0.724 |
| Gastric atrophy by SPT | ||||||
| Not severe | 209 | 13 (6.2) | 1 | 1 | ||
| Severe† | 44 | 6 (13.6) | 2.00 (0.76–5.28) | 0.161 | 1.77 (0.57–5.48) | 0.326 |
| IM (antrum) | ||||||
| Absent or mild | 125 | 8 (6.4) | 1 | 1 | ||
| Moderate or severe | 132 | 11 (8.3) | 1.74 (0.69–4.34) | 0.239 | 0.84 (0.28–2.54) | 0.761 |
| IM (body) | ||||||
| Absent or mild | 188 | 8 (4.3) | 1 | 1 | ||
| Moderate or severe | 69 | 11 (15.9) | 3.11 (1.24–7.80) | 0.016* | 4.12 (1.23–13.87) | 0.022* |
| Type of neoplasm | ||||||
| Low-grade dysplasia | 113 | 8 (7.1) | 1 | - | ||
| High-grade dysplasia | 25 | 3 (12.0) | 0.84 (0.22–3.26) | 0.803 | - | |
| Early gastric cancer | 119 | 8 (6.7) | 0.96 (0.25–3.75) | 0.951 | - | - |
| No. of neoplasm | ||||||
| Single | 239 | 17 (7.1) | 1 | - | ||
| Multiple | 18 | 2 (11.1) | 0.894 (0.20–4.00) | 0.883 | - | - |
| Location of neoplasm | ||||||
| Upper or middle third | 63 | 6 (9.5) | 1 | - | ||
| Lower third | 194 | 13 (6.7) | 0.60 (0.23–1.58) | 0.299 | - | - |
| Size of neoplasm, cm | ||||||
| ≤2 | 227 | 16 (7.0) | 1 | - | ||
| >2 | 30 | 3 (10.0) | 2.23 (0.63–7.82) | 0.212 | - | - |
MGN, metachronous gastric neoplasm; HR, hazard ratio; CI, confidence interval; H. pylori, Helicobacter pylori; SPT, serum pepsinogen test; IM, intestinal metaplasia.
*
p<0.05;
†
Severe atrophy was defined as pepsinogen I ≤30 and pepsinogen I/II ≤2.0.