Table 3.
Factors Affecting Discordance in Fibrosis Staging between Histology and Acoustic Radiation Force Impulse Velocity
| Variable | One-stage discordance (n=68, 64.8%) | Two-stage discordance (n=16, 15.2%) | |||
|---|---|---|---|---|---|
|
|
|
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| Univariate | Univariate | Multivariate | |||
|
|
|
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| p-value | OR (95% CI) | p-value | p-value | OR (95% CI) | |
| Clinical data | |||||
| Age, yr | 0.613 | - | 0.422 | - | - |
| Male gender | 0.229 | - | 0.276 | - | - |
| Body mass index, kg/m2 | 0.998 | - | 0.002 | 0.006 | 1.291 (1.075–1.551) |
| Total cholesterol, mg/dL | 0.505 | - | 0.916 | - | - |
| Serum albumin, g/dL | 0.335 | - | 0.247 | - | - |
| Total bilirubin, mg/dL | 0.324 | - | 0.378 | - | - |
| Aspartate aminotransferase, IU/L | 0.084 | - | 0.181 | - | - |
| Alanine aminotransferase, IU/L | 0.129 | - | 0.923 | - | - |
| Prothrombin time, INR | 0.995 | - | 0.739 | - | - |
| Platelet count, 109/L | 0.479 | - | 0.358 | - | - |
| HBV DNA, IU/L | 0.246 | - | 0.716 | - | - |
| HBeAg positivity | 0.185 | - | 0.438 | - | - |
| Histological data | |||||
| F3–4 (vs F0–2) | 0.042 | 0.426 (0.187–0.969) | 0.016 | 0.016 | 0.181 (0.045–0.730) |
| ARFI elastography | |||||
| Interquartile range, m/sec | 0.751 | - | 0.132 | - | - |
| Interquartile range/median | 0.423 | - | 0.145 | - | - |
| Interquartile range/mean | 0.903 | - | 0.644 | - | - |
OR, odds ratio; CI, confidence interval; INR, international normalized ratio; HBV, hepatitis B virus; HBeAg, hepatitis B e antigen; ARFI, acoustic radiation force impulse.