Table 3.
Diagnostic Performance of Controlled Attenuation Parameter for the Detection of ≥S2 and ≥S3 Steatosis
| All patients | NAFLD | ALD | |
|---|---|---|---|
| ≥S2 steatosis | |||
| AUROC (95% CI) | 0.789 (0.735–0.863) | 0.791 (0.691–0.892) | 0.780 (0.675–0.885) |
| CAP cutoff, dB/m | 250.0 | 255.5 | 245.0 |
| Sensitivity, % | 90.1 | 90.8 | 91.4 |
| Specificity, % | 45.3 | 60.0 | 62.2 |
| PPV, % | 70.9 | 85.2 | 53.3 |
| NPV, % | 75.6 | 72.0 | 85.0 |
| ≥S3 steatosis | |||
| AUROC (95% CI) | 0.843 (0.782–0.904) | 0.823 (0.740–0.907) | 0.867 (0.777–0.957) |
| CAP cutoff, dB/m | 289.5 | 290.5 | 279.5 |
| Sensitivity, % | 91.4 | 92.6 | 100.0 |
| Specificity, % | 66.2 | 59.5 | 68.1 |
| PPV, % | 38.6 | 43.9 | 25.8 |
| NPV, % | 97.1 | 95.9 | 100.0 |
NAFLD, nonalcoholic fatty liver disease; ALD, alcoholic liver disease; S2, moderate steatosis; AUROC, area under receiver operating characteristic curves; CI, confidence interval; CAP, controlled attenuation parameter; PPV, positive predictive value; NPV, negative predictive value; S3, severe steatosis.