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Simvastatin dose-dependently induces apoptosis and caspase-3 activation. The effect of simvastatin on apoptosis was directly evaluated by a cell death detection enzyme-linked immunosorbent assay (A) and a caspase-3 activity assay (B). *p<0.05 compared to the untreated control; †p<0.01 compared to the untreated control.
