Table 2. Cardiovascular Responses to Maximal Normoxic Cycle and KE Exercise in Control Subjects and CHF Patients.
| Cycle |
KE |
|||
|---|---|---|---|---|
| Control Subjects | CHF | Control Subjects | CHF | |
| Work load (W) | 148 ± 11 | 96 ± 8* | 35 ± 4 | 24 ± 4* |
| Pulm VO2 (l/min) | 2.03 ± 0.11 | 1.52 ± 0.15* | 1.08 ± 0.16 | 0.78 ± 0.04* |
| Pulm VO2 (ml/kg/min) | 21.2 ± 1.7 | 15.2 ± 1.1* | 11.3 ± 1.4 | 7.8 ± 0.5* |
| Pulm VCO2 (l/min) | 2.13 ± 0.16 | 1.69 ± 0.13* | 0.89 ± 0.10 | 0.73 ± 0.04* |
| RER | 1.05 ± 0.03 | 1.09 ± 0.02 | 0.86 ± 0.06 | 0.96 ± 0.06 |
| VE (l/min) | 83.2 ± 7.6 | 76.0 ± 5.0 | 36.8 ± 4.4 | 36.0 ± 3.0 |
| Cardiac output (l/min) | 15.5 ± 1.6 | 10.4 ± 1.1* | 10.3 ± 1.6 | 7.5 ± 0.7* |
| HR (beats/min) | 156 ± 11 | 148 ± 5 | 113 ± 8 | 112 ± 5 |
| Leg blood flow (l/min) | 4.93 ± 0.55 | 3.42 ± 0.27* | 3.34 ± 0.37 | 2.50 ± 0.21* |
| Leg blood flow (ml/min/100 g) | 94 ± 9.0 | 51 ± 5* | 152 ± 8 | 112 ± 10* |
| Leg O2 delivery (l/min) | 1.00 ± 0.11 | 0.65 ± 0.06* | 0.65 ± 0.07 | 0.45 ± 0.04* |
| Leg VO2 (l/min) | 0.75 ± 0.07 | 0.52 ± 0.04* | 0.46 ± 0.05 | 0.34 ± 0.02* |
| Leg VO2 (ml/min/100 g) | 11.7 ± 1.0 | 7.7 ± 0.5* | 21.1 ± 2.1 | 15.3 ± 1.3* |
| DMO2 (ml/min/mm Hg) | 18.5 ± 1.1 | 12.6 ± 0.7* | 11.1 ± 0.9 | 8.7 ± 0.7* |
| Fem arterial pressure (mm Hg) | 129 ± 18 | 115 ± 8 | 147 ± 12 | 117 ± 5* |
| Fem venous pressure (mm Hg) | 18 ± 4 | 14 ± 1 | 17 ± 5 | 17 ± 2 |
| Leg vasc res (mm Hg/ml/s) | 1.45 ± 0.29 | 1.91 ± 0.19 | 2.45 ± 0.33 | 2.54 ± 0.19 |
| CaO2 (ml/100 ml) | 20.3 ± 0.4 | 18.8 ± 0.5* | 19.5 ± 0.3 | 18.0 ± 0.6* |
| CaO2-CvO2 (ml/100 ml) | 15.4 ± 0.8 | 14.6 ± 0.5 | 13.7 ± 0.7 | 13.6 ± 0.5 |
| PaO2 (mm Hg) | 97 ± 7 | 99 ± 5 | 112 ± 4 | 102 ± 4 |
| PaCO2 (mm Hg) | 31.9 ± 1.9 | 28.5 ± 0.8* | 31.5 ± 0.9 | 30.6 ± 1.0* |
| SaO2(%) | 96 ± 1 | 96 ± 1 | 97 ± 1 | 97 ± 1 |
| [Hb] (g/dl) | 15.0 ± 0.3 | 13.9 ± 0.4* | 14.2 ± 0.2 | 13.2 ± 0.4* |
| pHa | 7.32 ± 0.02 | 7.37 ± 0.01* | 7.39 ± 0.01 | 7.41 ± 0.01* |
| [La]a (mmol/l) | 6.7 ± 1.0 | 5.4 ± 0.6 | 3.1 ± 0.4 | 2.6 ± 0.2 |
| PvO2 (mm Hg) | 21.8 ± 2.2 | 20.8 ± 1.3 | 23.4 ± 1.2 | 20.6 ± 1.0 |
| PvCO2 (mm Hg) | 68.6 ± 4.2 | 58.5 ± 1.7* | 65.7 ± 2.5 | 63.8 ± 2.3 |
| SvO2 (%) | 23 ± 4 | 22 ± 2 | 29 ± 3 | 23 ± 2 |
| PcapO2 (mm Hg) | 41.1 ± 1.7 | 39.6 ± 1.2 | 41.6 ± 0.9 | 39.2 ± 0.8 |
Cardiovascular responses to maximal normoxic cycle and knee-extensor (KE) exercise in control subjects (n = 8) and patients with chronic heart failure (CHF) (n = 12). Results are expressed as mean ± SEM.
p < 0.05 (CHF vs. control subjects).
CaO2 = arterial oxygen content; CaO2-CvO2 = arterial – venous oxygen content difference; DmO2 = muscle oxygen diffusional conductance; [Hb]a = arterial hemoglobin concentration; HR = heart rate; [La]a = arterial lactate concentration; Leg vasc res = 1-leg vascular resistance; Leg VO2 = 1-leg oxygen uptake; PaO2 and PaCO2 = oxygen and carbon dioxide partial pressures in arterial blood; PcapO2 = calculated partial pressure of oxygen in the capillaries of the exercising muscle; pHa = arterial pH; pulm VO2 = pulmonary peak oxygen uptake; pulm VCO2 = pulmonary carbon dioxide uptake; PvO2 and PvCO2 = oxygen and carbon dioxide partial pressures in femoral venous blood, respectively; RER = respiratory exchange ratio; SaO2 = arterial oxygen saturation; SvO2 = venous oxygen saturation; VE = ventilation.