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A model for hExo1 regulation by human SSBs. SOSS1 cooperatively loads hExo1 on DNA ends. As hExo1 resects the DNA, SOSS1 is replaced by hRPA. hRPA displaces hExo1, but another hExo1 molecule can rebind at the site. This cycle of binding, displacement, and rebinding results in distributive resection. Additional factors (e.g., BLM, MRN, and PCNA; not included for clarity) may also promote resection in the presence of hRPA.
