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. 2016 Feb 16;113(9):2484–2489. doi: 10.1073/pnas.1518934113

Fig. 3.

Fig. 3.

Identification of the C terminus of mature Core in extracellular HCV virions. (A) Amino acid sequence of Core corresponding to residues 1–191 of the J6 HCV polyprotein, genotype 2a. The underlined sequences were identified in the database search. Trypsin cleavage sites are shown in bold, whereas the most C-terminal peptide cleavage site is shown in red. (B) Schematic representation of the junction between Core and E1. The predicted sequence and calculated protonated masses (MH+) of clone 2 Core peptide generated by cleavage with exogenous trypsin protease and the host SPP are indicated in red and match the observed data. Full-length Core (191 aa) is generated by cleavage of the signal peptidase (SP), whereas mature Core is produced by SPP-mediated cleavage at position 177.