Fig. 1.
XP-C patients. (A) XP78BR, aged 12 y; note lentigines on face. (B) XP22BR, aged 38 y; note the extensive pigmentary changes. (C) XP107BR, aged 37 y; note the almost complete absence of pigmentary changes, despite not being diagnosed until 34 y of age. (D) Site of excised melanoma from XP107BR. (E) UDS, measured as incorporated 3H-thymidine cpm per 105 cells following UV irradiation of XP107BR with different UVC doses compared with two normal controls: 1BR2 and 48BR. (F) Alignment of XPC protein from human and mouse and yeast Rad4 in the region around Tyr585 (indicated in green) that is mutated in XP107BR. (G) Crystal structure of Rad4 (22) with Tyr379 (corresponding to Tyr585 in human XPC) indicated in red in the structure and the schematic below.