Fig. 1.

Translational regulation of mRNA coding for secreted proteins during in vivo oocyte maturation. (A) Pie chart reporting different classes of transcripts for secreted proteins according to their polysome recruitment from GV to MII. The number of transcripts constitutively translated, those decreased (repressed) and increased (activated), is reported. See Dataset S1 for the full list. FDR < 5% and q < 0.05 were used in this analysis. Secreted proteins were grouped according to function: (B) peptidases, (C) zona pellucida and extracellular matrix proteins, (D) transforming growth factor β superfamily, (E) fibroblast growth factor family, and (F) cytokines/chemokines. Error bars correspond to the SEM, and data are from three biologically different samples. The dataset in ref. 18 was used.