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. 2016 Feb 16;113(9):E1246–E1255. doi: 10.1073/pnas.1522830113

Fig. S7.

Fig. S7.

Model for NC death in late oogenesis. Stretch FCs surround NC remnants during late oogenesis and nonautonomously promote their death. Draper becomes activated by an unidentified signal to promote intracellular trafficking and NC death. Ced-12 is activated by an unknown engulfment receptor and activates JNK, which promotes enrichment of Draper, causing NC death. Ced-12 additionally has a function independent of Draper. Nonautonomous mechanisms play a major role in promoting NC death, but NCs also use autonomous cell death mechanisms.