Fig. S5.

Direct intrahippocampal injection of IgG reduces Rag-5xfAD plaque load in vivo. (A and B) Representative immunohistochemical images demonstrate significantly more amyloid present in the PBS-injected side (A) compared with the IgG-injected side (B). (C and D) IMARIS-based 3D quantification of Aβ confirms a significant reduction in both total Aβ volume and the number of large plaques, whereas the number of small plaques was almost significantly reduced (P = 0.066) as well. Data are represented as mean ± SEM; n = 3 animals/genotype. Student’s t test (paired, two-tailed), ^§P < 0.01.