Table 2.
The effect of ether/ethanol volume ratio on particle size, drug loading amount, and production yield of 5-fluorouracil hollow microspheresa
| Ether/ethanol (v/v) | Particle size distribution
|
Drug loading (%) | Production yield (%) | ||
|---|---|---|---|---|---|
| <450 µm (%) | 450–600 µm (%) | >600 µm (%) | |||
| 0:10.0 | – | – | – | – | 0 |
| 0.5:10.0 | 19.5±2.1 | 60.1±2.5 | 20.4±2.1 | 21.4±1.3 | 58.4±1.5 |
| 1.0:10.0 | 18.1±1.6 | 62.9±4.2 | 19.0±1.7 | 26.7±1.5 | 71.1±2.3 |
| 1.5:10.0 | 20.0±2.4 | 61.2±3.7 | 18.8±1.9 | 20.9±1.2 | 32.2±1.2 |
Note:
a
Mean ± standard deviation.
Abbreviation: v, volume.