Table 3.

The effect of PVP/EC weight ratio on particle size, drug loading amount, and production yield of 5-fluorouracil hollow microspheres^a

PVP/EC (w/w)	Particle size distribution			Drug loading amount (%)	Production yield (%)
	<450 µm (%)	450–600 µm (%)	>600 µm (%)
0.0:10.0	18.1±1.6	62.9±4.2	19.0±1.7	26.7±1.5	71.1±2.3
0.2:10.0	17.5±2.1	61.3±2.5	21.2±1.3	27.1±1.2	70.3±2.6
0.5:10.0	15.1±1.6	61.7±4.2	23.2±1.8	27.3±1.9	69.8±2.7
1.0:10.0	13.2±1.1	59.2±5.3	27.6±0.8	28.1±1.8	72.2±2.3
2.0:10.0	10.1±1.1	56.2±5.7	33.7±0.8	29.8±1.5	60.5±3.4

Note:

^aMean ± standard deviation.

Abbreviations: EC, ethyl cellulose; PVP, polyvinyl pyrrolidone; w, weight.