Table 5.

Pharmacokinetic parameters of 5-FU after oral administration of 5-FU hollow microspheres and its solid microspheres and powder to rabbits at a dose of 50 mg/kg body weight^a

	AUC(0–t) (mg/L* hours)	MRT(0–t) (hours)	Cmax (mg/L)	Tmax (hours)	t1/2 (hours)
5-FU hollow microspheres	12.53±1.65*	7.65±0.97*	1.64±0.21*	2.00±0.22*	15.43±2.12*
5-FU solid microspheres	7.80±0.83	3.61±0.41	2.25±0.26	1.00±0.15	2.25±0.22
5-FU powder	5.82±0.83	2.34±0.35	2.55±0.19	0.75±0.11	1.43±0.18

Notes:

^aMean ± standard deviation.

^*P<0.01 vs 5-FU solid microspheres and powder as the controls.

Abbreviations: C_max, maximum plasma drug concentration; 5-FU, 5-fluorouracil; MRT, mean residence time; T_max, time to reach the maximum plasma drug concentration; t_1/2, elimination half-life; AUC, area under curve.