Table 1. Patient characteristics.
KT Patients (n = 222) | No Rejection (n = 192) (86%) | Early Rejection (n = 30) (14%) | P |
---|---|---|---|
Age recipient | 57 (46–64) | 55 (47–63) | 0.60 |
Age Donor | 52 (40–62) | 58 (50–65) | 0.024 |
Male gender recipient | 118 (61%) | 14 (63%) | 0.84 |
Male gender donor | 94 (49%) | 13 (43%) | 0.57 |
CMV-seropositivity recipient | 118 (61%) | 15 (50%) | 0.23 |
CMV-serostatus donor/recipient | |||
-/- | 42 (22%) | 10 (33%) | 0.17 |
-/+ | 38 (20%) | 5 (17%) | 0.69 |
+/- | 32 (17%) | 5 (17%) | 1.00 |
+/+ | 80 (42%) | 10 (33%) | 0.39 |
Anti-CMV IgG titer recipient (AU/mL) | 65 (42–105) | 58 (47–86) | 0.75 |
Mismatch HLA class I | 2 (2–3) | 3 (2–3) | 0.15 |
Mismatch HLA class II | 1 (1–2) | 1 (1–2) | 0.31 |
Mismatch HLA class I and II | 4 (3–5) | 4 (3–5) | 0.11 |
PRA current (%) | 0 (0–4) | 0 (0–4) | 0.52 |
PRA historic (%) | 4 (0–4) | 4 (0–29) | 0.039 |
Amount of KT | 1 (1–1) | 1 (1–1) | 0.63 |
Warm ischemia time | 20 (16–24) | 21 (16–25) | 0.69 |
Cause of CKD | |||
Nephrosclerosis/atherosclerosis/hypertension | 44 (23%) | 7 (23%) | 0.96 |
Primary glomerulopathies | 26 (14%) | 4 (13%) | 1.00 |
Diabetes | 41 (21%) | 2 (7%) | 0.06 |
Urinary tract infections/stones | 5 (3%) | 1 (3%) | 0.59 |
Reflux nephropathy | 9 (5%) | 1 (0%) | 1.00 |
Polycystic Kidney Disease | 33 (17%) | 7 (23%) | 0.42 |
Other | 26 (14%) | 5 (17%) | 0.58 |
Unknown | 8 (4%) | 3 (10%) | 0.17 |
Pre-emptive KT | 75 (39%) | 17 (57%) | 0.07 |
Genetically-related KT | 82 (43%) | 6 (20%) | 0.018 |
Acute rejection type | |||
Cellular rejection | 25 (83%) | ||
Antibody-mediated rejection | 1 (3%) | ||
Mixed rejection | 4 (13%) |