Table 5.
Toxicity functions at the gene level for each T2D subtype.
| Toxicity functions | Subtype1 | Subtype2 | Subtype3 | Genes |
|---|---|---|---|---|
| Biliary hyperplasia | 3.5 × 10−3 | ns | ns | CFTR, PKHD1 |
| Glutathione depletion in liver | 3.5 × 10−3 | ns | ns | LEPR, TGFB1 |
| Liver fibrosis | 3.5 × 10−3 | ns | ns | TGFB1, LEPR, TGFB2, PKHD1 |
| Glomerular injury | 4.7 × 10−3 | ns | ns | FYN, TGFB1, LEPR, RARA, TNS1, PKN1, PTGER1, BCL2 |
| Renal hypertrophy | 4.7 × 10−3 | ns | ns | TGFB1, LEPR, RARA, BCL2 |
| Liver damage | 5.1 × 10−3 | ns | ns | SLC10A1, TGFB1, IGF1R, GABBR1, SERPINA1, CD274, PARK2, PTGER1 |
| Liver inflammation/hepatitis | 5.1 × 10−3 | ns | ns | AKAP12, SLC10A1, TGFB1, PDE3A, IGF1R, GABBR1, CD274, PARK2 |
| Renal proliferation | 7.6 × 10−3 | ns | ns | PRKG1, TGFB1, UNC5B, TTLL4, CRK, ZNF512B, DLC1, BCL2, UNC5C, AFF1 |
| Renal degeneration | 8.0 × 10−3 | ns | ns | TGFB1, TNS1, BCL2 |
| Cardiac arrhythmia | ns | 1.0 × 10−3 | ns | KCND3, HCN4, KCNG2, KCNQ1, CNTN5 |
| Bradycardia | ns | 4.9 × 10−3 | ns | HCN4, KCNQ1 |
| Cardiac arteriopathy | ns | 9.3 × 10−3 | 4.8 × 10−6 | Subtype 2: SAMD12, KALRN, ITGA8, PDE5A, DOCK4, CNTN6, PRKCH, CSMD2, CPEB3, CNTN5 Subtype 3: CERS6, CLIC5, ZMYM2, CDCP1, ABCG1, FRMD4A, PDE4B, PTPRM, ABCA1, F2, SPATA5, AKAP13, MCF2L, PBX3, CNTNAP5, FMN2, CACNA2D1, SLC8A1, ESR2 |
| Liver fibrosis | ns | ns | 3.3 × 10−3 | FGF2, PLAUR, BMP7, CC2D2A, F2, HSPB1 |
| Congenital heart anomaly | ns | ns | 5.8 × 10−3 | DNAH11, BICC1, PDS5B, INVS |