Table 2. Serum lipid analysis of low-density lipoprotein receptor-knockout (LDLr KO) mice fed a HFD with treatment of pravastatin or pravastatin plus sarpogrelate.

Milligrams/deciliter	NFD	HFD	HFD + PRA 40 mg/kg	HFD + PRA 40 mg/kg + SAR 50 mg/kg
Total cholesterol	351.1 ± 17.67	2132 ± 111.1	1353 ± 104.3 ***	1446 ± 84.13 ***
Triglycerides	113.3 ± 11.94	1048 ± 195.1	232.0 ± 33.29 ***	377.1 ± 18.00 **
HDL cholesterol	100.7 ± 3.496	87.25 ± 5.593	89.50 ± 2.693	84.50 ± 3.813
LDL cholesterol	111.1 ± 7.818	787.5 ± 40.64	512.5 ± 32.14 **	542.3 ± 34.37 **

Data represented as mean ± standard error and significance was analyzed by Student’s t-test (**,*** denote significant difference to HFD group, **P < 0.01, ***P < 0.001, n = 7–8/group).

Abbreviations: NFD, normal fat diet; HFD, high fat diet; SAR, sarpogrelate; PRA, pravastatin