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. Author manuscript; available in PMC: 2017 Feb 1.
Published in final edited form as: J Pharm Sci. 2016 Jan 12;105(2):989–995. doi: 10.1002/jps.24632

Figure 4. C2E5 Hydrolysis by Human, Dog, Sprague-Dawley Rat Plasma Fractions.

Figure 4

Fifty μM [14C]-C2E5 was added directly to plasma (pre-warmed for 5 min at 37°C). The reactions were terminated at the indicated time points by addition of an equal volume of cold acetonitrile followed by centrifugation (2X) at 14,000 × g for 10 min at 4°C. The percent (A) C2E5 remaining and (B) human, (C) dog and (D, E) rat metabolic profiles [C2E4 (◆); C2E3 (○); C2E2 (▲); C2E1 (□); DTPA (●)] were determined by radio-HPLC. All assays were performed in triplicate and were expressed as the mean ± S.D.