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. Author manuscript; available in PMC: 2016 Mar 7.
Published in final edited form as: Dev Biol. 2010 May 19;344(1):377–389. doi: 10.1016/j.ydbio.2010.05.016

Fig. 5.

Fig. 5

Knockdown of Chordin truncates the head. Side views, anterior to left, except dorsal views in S,V and cross sections in A’, D’. (A, D, G, J, M, P) Mid gastrulae. (B, E, H, K, N, Q, T, W, A’, B’,D’, E’) Mid-neurulae (15 hrs). (U, X) Late neurulae (22 hrs). (C, F, I, L, O, R, U, X, C’ F’) Early larvae (36 hrs). (A,D) Chordin expression is unaffected. (B,C,E,F) Otx expression in the CNS is reduced (arrow). (G,J) Cerberus expression is eliminated. (H,K,I,L) FoxQ2 expression eliminated. (M, P) Sox1/2/3 expression in CNS unaffected. (N, O, Q, R) Wnt3 expression unaffected, but the forebrain/midbrain, which normally does not express Wnt3, is reduced. (S,V) Late gastrula; dorsal views. BMP2/4 partially down regulated in neural plate. (T,W,U,X) Hex expression in anterior endoderm reduced. Arrowhead in U,X indicates presumptive endostyle (A’, F’) Brachyury expression in notochord largely unaffected (A’-F’). In some neurulae (D’, E’), the domain extends anteriorly. A’-A’ and D’, D’ indicate levels of cross sections in A’ and D’.