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. Author manuscript; available in PMC: 2016 Nov 1.
Published in final edited form as: Biol Blood Marrow Transplant. 2015 Jun 11;21(11):1914–1920. doi: 10.1016/j.bbmt.2015.06.003

Table 2. Dose Escalation.

Level Vorinostat (mg/day) Gemcitabine (mg/m2/day) Busulfan (μm-min/day or mg/m2/day) Melphalan (mg/m2/day)
Loading Dose Continuous Infusion*
1 200 75 2100 4000 or 105 60
2 300 75 2100 4000 or 105 60
3 400 75 2100 4000 or 105 60
4 500 75 2100 4000 or 105 60
5 600 75 2100 4000 or 105 60
6 600 75 2400 4000 or 105 60
7 600 75 2700 4000 or 105 60
8 700 75 2700 4000 or 105 60
9 800 75 2700 4000 or 105 60
10 900 75 2700 4000 or 105 60
11 1000 75 2700 4000 or 105 60
*

Continuous infusion of gemcitabine administered at 10 mg/m2/minute.