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. 2016 Mar 8;7:306. doi: 10.3389/fmicb.2016.00306

Figure 5.

Figure 5

Loss of proper cell wall mannosylation affects the ability of C. parapsilosis to stimulate cytokine production by human PBMCs. Yeast cells where co-incubated with human PBMCs, the supernatant saved and used to quantify pro- and anti-inflammatory cytokines. Results (means ± SD) where obtained using samples from six donors, each assayed in duplicate wells. The strains used are: CLIB-214 (WT), CPRI (WT(R)), AP (OCH1/och1Δ), AP-1 (och1Δ/och1Δ), and AP-2 (och1Δ + OCH1). *P < 0.05, when compared with live cells; †P < 0.05, when compared with untreated cells; ‡P < 0.05, when compared with cells subjected to the same treatment.