Table 3.
Multivariate analysis of prognostic factors as covariables with CD133 methylaiton status or expression for glioma outcome
| Variable | PFS | OS | ||
|---|---|---|---|---|
| HR (95 % CI) | p | HR (95 % CI) | p | |
| CD133 methylation status | n = 152 | n = 170 | ||
| Unmethylation | 1 | 1 | ||
| Methylation | 2.61 (1.57–4.34) | <0.001 | 2.87 (1.74–4.73) | <0.001 |
| WHO grade | ||||
| WHO2 | 1 | 1 | ||
| WHO3 | 4.49 (2.14–9.38) | <0.001 | 7.06 (3.34–14.91) | <0.001 |
| WHO4 | 7.74 (3.90–15.33) | <0.001 | 11.51 (5.86–22.61) | <0.001 |
| Patient age | 1.021(1.00–1.04) | 0.016 | – | 0.054 |
| Extent of resection | 0.72 (0.55–0.94) | 0.016 | 1.40 (0.71–2.76) | 0.330 |
Backword stepwise (likelihood ratio) Cox regression model