| Fingolimod can cross the blood–brain barrier and directly influence central nervous system (CNS) pathogenesis in relapsing forms of multiple sclerosis (RMS). |
| In animal models of RMS, fingolimod directly promotes myelin integrity. |
| Fingolimod exerts effects on each of the key brain cells involved in RMS pathology, and sphingosine 1-phosphate modulation of CNS cells may affect clinical outcomes. |
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