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R1398 is located in close proximity to the N1437, R1441, and Y1699 PD mutants location. A magnified image of the C. tepidum Roco protein structure showing the close spatial proximity of R1398 to three sites of pathogenic mutation, N1437, R1441, and Y1699. Mutations at all four residues are expected to alter intramolecular interactions between Roc and COR domains. Note that A1442 has also been implicated as the site of a PD-causing mutation (Huang et al., 2007).
