Table 2.

Summary of studies about premedication with pronase for visualization of the mucosa during advanced endoscopy

Examination	Ref.	Year	Study design	Premedication group (n)	Mucosal visibility
Chromoendoscopy	Fujii et al[8]	1998	Prospective	A: DMPS (34) B: DMPS + SB (32) C: DMPS + SB + pronase (34)	C > A, B
NBI endoscopy	Cha et al[17]	2014	Prospective	A: Pronase + SB (28) B: Simethicone (27)	A > B
ME-NBI	Kim et al[7]	2015	Prospective	A: Simethicone + SB + pronase (71) B: Simethicone (72)	A > B
EUS	Sakai et al[24]	2003	Prospective	A: DMPS (29) B: DMPS + SB (29) C: DMPS + SB + pronase (29)	C > A, B
	Han et al[25]	2011	Prospective	A: Saline (60) B: Pronase + SB (62) C: Pronase + SB + simethicone (61)	B > A > C

NBI: Narrow-band imaging; ME-NBI: Magnifying endoscopy with narrow-band imaging; EUS: Endoscopic ultrasonography; DMPS: Dimethylpolysiloxane; SB: Sodium bicarbonate.