Table 1.
Controls (18) |
C9orf72 (17) |
MAPT (20) |
GRN (7) |
C9orf72 vs Controls |
MAPT vs Controls |
GRN vs Controls |
C9orf72 |
MAPT |
GRN |
GRN vs C9orf72 |
GRN vs MAPT |
C9orf72 vs MAPT |
|||||
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Structure | Mean | SD | Mean | SD | Mean | SD | Mean | SD | p-Value | p-Value | p-Value | % difference vs controls | % difference vs controls | % difference vs controls | p-Value | p-Value | p-Value |
Lobule I–IV | 6236 | 670 | 6363 | 861 | 6250 | 433 | 7053 | 674 | 0.660 | 0.534 | 0.012 | − 2.0 | − 0.2 | − 13.1 | 0.099 | 0.013 | 0.775 |
Lobule V | 8911 | 897 | 8623 | 905 | 8922 | 742 | 9371 | 737 | 0.503 | 0.553 | 0.125 | 3.2 | − 0.1 | − 5.2 | 0.034 | 0.145 | 0.311 |
Lobule VI | 15639 | 1452 | 14587 | 2000 | 15277 | 1390 | 16590 | 1930 | 0.067 | 0.534 | 0.244 | 6.7 | 2.3 | − 6.1 | 0.034 | 0.104 | 0.133 |
Lobule VIIa-Crus I | 21091 | 2467 | 17885 | 1984 | 20360 | 3303 | 19298 | 2237 | < 0.0005 | 0.675 | 0.125 | 15.2 | 3.5 | 8.5 | 0.099 | 0.498 | 0.013 |
Lobule VIIa-Crus II | 17610 | 2311 | 15807 | 2863 | 16015 | 1822 | 17666 | 752 | 0.067 | 0.033 | 0.534 | 10.2 | 9.1 | − 0.3 | 0.147 | 0.036 | 0.845 |
Lobule VIIb | 7565 | 802 | 7330 | 976 | 7488 | 781 | 7460 | 611 | 0.483 | 0.515 | 0.534 | 3.1 | 1.0 | 1.4 | 0.951 | 0.850 | 0.729 |
Lobule VIIIa | 7799 | 704 | 7724 | 927 | 7957 | 558 | 8033 | 756 | 0.909 | 0.361 | 0.495 | 1.0 | − 2.0 | − 3.0 | 0.534 | 0.766 | 0.517 |
Lobule VIIIb | 7451 | 900 | 6926 | 894 | 7318 | 1077 | 7233 | 834 | 0.245 | 0.806 | 0.790 | 7.0 | 1.8 | 2.9 | 0.288 | 0.685 | 0.270 |
Lobule IX | 6200 | 828 | 5563 | 799 | 5520 | 709 | 5659 | 864 | 0.013 | 0.010 | 0.158 | 10.3 | 11.0 | 8.7 | 0.318 | 0.533 | 0.988 |
Lobule X | 860 | 88 | 850 | 108 | 909 | 124 | 882 | 146 | 0.883 | 0.228 | 1.000 | 1.1 | − 5.7 | − 2.6 | 0.757 | 0.607 | 0.149 |
Vermis | 5034 | 375 | 4624 | 584 | 4554 | 412 | 4862 | 408 | 0.025 | 0.001 | 0.297 | 8.1 | 9.5 | 3.4 | 0.260 | 0.145 | 0.940 |
Dentate nuclei | 3291 | 426 | 3303 | 406 | 3214 | 422 | 3325 | 524 | 1.000 | 0.361 | 0.836 | − 0.4 | 2.3 | − 1.0 | 0.951 | 0.766 | 0.341 |
Interposed nuclei | 392 | 44 | 351 | 31 | 357 | 31 | 394 | 54 | 0.004 | 0.007 | 0.836 | 10.4 | 8.9 | − 0.4 | 0.099 | 0.104 | 0.821 |
Fastigial nuclei | 57 | 10 | 51 | 6 | 51 | 6 | 56 | 10 | 0.062 | 0.033 | 0.836 | 10.5 | 11.1 | 0.9 | 0.147 | 0.104 | 0.988 |