Table 3.
Group comparison | Cluster size | T-value (voxel) | Anatomical region | Assigned white matter structure |
---|---|---|---|---|
C > FEP | 251 | 4.25 | Frontal lobe, medial orbital gyrus R | |
C < FEP | 209 | 4.37 | Parietal lobe, region of gyrus Andrei Retzii L | Subcallosal white matter, Posterior cingulum bundle |
C > REP | 3606* | 7.08 | Occipital lobe, median area L | Inferior fronto-occipital fasciculus |
615 | 4.77 | Cuneus L/R | ||
194 | 4.03 | Frontal lateral white matter compartment R | Corona radiata, Corticothalamic tract | |
519 | 3.49 | Frontal lobe, F1 region L | ||
C < REP | 299 | 4.00 | Temporal lobe, superior temporal gyrus, Angular gyrus R | Inferior longitudinal fasciculus, Arcuate fasciculus |
711 | 3.97 | Cerebellum L | ||
FEP > REP | 1033 | 5.40 | Occiptal lobe, median and basal parts L | Inferior fronto-occipital fasciculus |
2064 | 4.82 | Middle and upper pontine area, lateral circumference, cerebellar peduncle L | Corticospinal tract | |
209 | 4.57 | Parahippocampal area T4/T5 L | Fornix | |
519 | 4.04 | Middle and upper pontine area, lateral circumference, cerebellar peduncle R | Corticospinal tract | |
265 | 3.78 | Frontal lobe, F1 region, middle part R | ||
FEP < REP | n.s. | n.s. | n.s. | n.s. |
Between-group differences in white matter structure were found in reported clusters. Only clusters showing group differences at a significance level of p < 0.001 and exceeding the expected number of voxels per cluster according to the Gaussian Random Field theory are reported.
p < 0.001 (cluster-level, FWE corrected for multiple comparisons). Anatomic labeling, corresponding cluster size and T-value are shown for each cluster. The type of group comparison is indicated in the form A < / > B, where A > B indicates lower white matter in group B compared to A and vice versa. Lateralization is marked with L for left and R for right hemisphere. Anatomical names of white matter structures were assigned using Mori: MRI Atlas of Human White Matter (Mori et al., 2005). C, control; FEP, first episode patients; REP, recurrent episode patients. C, control; FEP, first episode patients; REP, recurrent episode patients.