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. 2016 Mar 8;10:33. doi: 10.3389/fncel.2016.00033

Table 3.

Results of group comparison of white matter brain structure between controls and patient groups (VBM-based analysis).

Group comparison Cluster size T-value (voxel) Anatomical region Assigned white matter structure
C > FEP 251 4.25 Frontal lobe, medial orbital gyrus R
C < FEP 209 4.37 Parietal lobe, region of gyrus Andrei Retzii L Subcallosal white matter, Posterior cingulum bundle
C > REP 3606* 7.08 Occipital lobe, median area L Inferior fronto-occipital fasciculus
615 4.77 Cuneus L/R
194 4.03 Frontal lateral white matter compartment R Corona radiata, Corticothalamic tract
519 3.49 Frontal lobe, F1 region L
C < REP 299 4.00 Temporal lobe, superior temporal gyrus, Angular gyrus R Inferior longitudinal fasciculus, Arcuate fasciculus
711 3.97 Cerebellum L
FEP > REP 1033 5.40 Occiptal lobe, median and basal parts L Inferior fronto-occipital fasciculus
2064 4.82 Middle and upper pontine area, lateral circumference, cerebellar peduncle L Corticospinal tract
209 4.57 Parahippocampal area T4/T5 L Fornix
519 4.04 Middle and upper pontine area, lateral circumference, cerebellar peduncle R Corticospinal tract
265 3.78 Frontal lobe, F1 region, middle part R
FEP < REP n.s. n.s. n.s. n.s.

Between-group differences in white matter structure were found in reported clusters. Only clusters showing group differences at a significance level of p < 0.001 and exceeding the expected number of voxels per cluster according to the Gaussian Random Field theory are reported.

*

p < 0.001 (cluster-level, FWE corrected for multiple comparisons). Anatomic labeling, corresponding cluster size and T-value are shown for each cluster. The type of group comparison is indicated in the form A < / > B, where A > B indicates lower white matter in group B compared to A and vice versa. Lateralization is marked with L for left and R for right hemisphere. Anatomical names of white matter structures were assigned using Mori: MRI Atlas of Human White Matter (Mori et al., 2005). C, control; FEP, first episode patients; REP, recurrent episode patients. C, control; FEP, first episode patients; REP, recurrent episode patients.