Table 4.

Results of pairwise group comparison of associations between S100B concentrations and white matter brain structure (VBM-based interaction analysis).

Interaction	Cluster Number	Cluster Size	T-Value (voxel)	Anatomical region	Assigned white matter structure
C > FEP	1	175	3.80	Temporal lobe, superior temporal gyrus L	Inferior longitudinal fasciculus Arcuate fasciculus
	2	880	5.13	Temporal lobe, superior temporal gyrus R	Inferior longitudinal fasciculus Arcuate fasciculus
	3	400	4.17	Dorsal parietal white matter compartment Postcentral region R	Superior longitudinal fasciculus
C < FEP	4	1214	5.55	Parietal white matter compartment Postcentral region R	Posterior cingulum bundle
C > REP	n.s.	n.s.	n.s.	n.s.
C < REP	5	818	4.28	Temporal lobe, superior temporal gyrus Angular gyrus L	Superior longitudinal fasciculus Arcuate fasciculus
	6	617	4.58	Parietal white matter compartment Postcentral region R	Posterior cingulum bundle
FEP > REP	n.s.	n.s.	n.s.	n.s.
FEP < REP	7	416	4.19	Temporal lobe, superior temporal gyrus, Insula R	Inferior longitudinal fasciculus
	8	945	5.32	Temporal lobe, T1/T2 region	Arcuate fasciculus
	9	1289	4.84	Fronto-parietal white matter compartment R	Superior longitudinal fasciculus
	10	220	4.06	Parietal lobe, Postcentral region

Abbreviations, labeling and data structure as in Table 3. Interaction type is indicated in the form A < / > B, whereby A > B indicates a significantly steeper gradient of regression (association between S100B and white matter) of A as compared to B and vice versa. Clusters are numbered for easier identification in figures and discussion. C, control; FEP, first episode patients; REP, recurrent episode patients.