Table 1.
Hematology and Coagulation Panel for Targeted S-Nitrosyl Nanofiber
| Targeted SNO nanofiber | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Control group | 3 h | Day 1 | Day 2 | Day 3 | Day 7 | |||||||
| Mean | SEM | Mean | SEM | Mean | SEM | Mean | SEM | Mean | SEM | Mean | SEM | |
| Hematology | ||||||||||||
| White blood cells (103/μl) | 6.5 | ±1.6 | 7.8 | ±0.6 | 5.4 | ±0.9 | 6.1 | ±1.0 | 4.1 | ±0.4 | 6.3 | ±1.3 |
| Red blood cells (106/μl) | 7.3 | ±0.6 | 9.4 | ±0.2 | 7.5 | ±0.4 | 7.7 | ±0.1 | 8.0 | ±0.2 | 7.6 | ±0.2 |
| Hemoglobin (g/dl) | 13.9 | ±1.1 | 17.4 | ±0.5 | 13.7 | ±0.6 | 14.2 | ±0.6 | 14.8 | ±0.5 | 14.0 | ±0.3 |
| Mean corpuscular volume (fl) | 55.7 | ±0.6 | 52.8 | ±1.0 | 52.8 | ±0.5 | 54.0 | ±1.0 | 53.7 | ±0.3 | 53.3 | ±0.9 |
| Differential (%) | ||||||||||||
| Segmented Neutrophils | 23.3 | ±5.2 | 58.1* | ±3.6 | 20.6 | ±1.6 | 15.3 | ±2.4 | 13.8 | ±3.7 | 13.8 | ±0.2 |
| Lymphocytes | 72.3 | ±5.4 | 36.2* | ±4.7 | 75.7 | ±1.7 | 79.8 | ±2.5 | 82.5 | ±3.3 | 82.4 | ±0.4 |
| Monocytes | 2.5 | ±0.3 | 4.9 | ±1.1 | 1.9 | ±0.2 | 2.5 | ±0.1 | 2.4 | ±0.6 | 1.6 | ±0.3 |
| Eosinophils | 1.4 | ±0.3 | 0.6 | ±0.3 | 1.2 | ±0.1 | 1.6 | ±0.3 | 1.6 | ±0.3 | 1.6 | ±0.1 |
| Basophils | 0.13 | ±0.04 | 0.15 | ±0.08 | 0.10 | ±0.03 | 0.17 | ±0.07 | 0.13 | ±0.03 | 0.23 | ±0.03 |
| Coagulation panel | ||||||||||||
| Platelet count (103/μl) | 544 | ±120 | 549 | ±91 | 984 | ±59 | 906 | ±81 | 830 | ±79 | 902 | ±45 |
| Prothrombin time (s) | 18.2 | ±2.4 | 18.1 | ±1.2 | 24.1 | ±6.4 | 14.7 | ±0.3 | 17.3 | ±0.3 | 21.6 | ±1.9 |
| Partial thromboplastin time (s) | 52 | ±4 | 57 | ±5 | 57 | ±10 | 43 | ±2 | 38 | ±4 | 68 | ±10 |
Bold denotes statistical significance.
*
p < 0.05 with respect to the control group. N = 3–6 animals per group.
SEM, standard error of the mean; SNO, S-nitrosyl.