Table 2.
Hematology and Coagulation Panel for Targeted SH Nanofiber
| Targeted SH nanofiber | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Control group | 3 h | Day 1 | Day 2 | Day 3 | Day 7 | |||||||
| Mean | SEM | Mean | SEM | Mean | SEM | Mean | SEM | Mean | SEM | Mean | SEM | |
| Hematology | ||||||||||||
| White blood cells (103/μl) | 6.5 | ±1.6 | 6 | ±2 | 3.5* | ±0.5 | 3.5* | ±1 | 5.5 | ±0.6 | 3.8 | ±0.8 |
| Red blood cells (106/μl) | 7.3 | ±0.6 | 7.1 | ±0.4 | 7.4 | ±0.5 | 6.5 | ±0.6 | 7.8 | ±0.2 | 5.4 | ±0.9 |
| Hemoglobin (g/dl) | 13.9 | ±1.1 | 13.1 | ±0.7 | 13.9 | ±0.8 | 12 | ±1 | 14.6 | ±0.2 | 10.1 | ±1.5 |
| Mean corpuscular volume (fl) | 55.7 | ±0.6 | 54.6 | ±0.9 | 54.5 | ±0.7 | 54 | ±1 | 55 | ±1 | 52.7 | ±1.2 |
| Differential (%) | ||||||||||||
| Segmented Neutrophils | 23.3 | ±5.2 | 51* | ±7 | 26 | ±3 | 21 | ±4 | 25 | ±2 | 10.2 | ±1.1 |
| Lymphocytes | 72.3 | ±5.4 | 44* | ±8 | 70 | ±3 | 75 | ±4 | 70 | ±3 | 86.4 | ±1.4 |
| Monocytes | 2.5 | ±0.3 | 2.3 | ±0.4 | 2.4 | ±0.4 | 2.1 | ±0.2 | 2 | ±0.4 | 1.3 | ±0.2 |
| Eosinophils | 1.4 | ±0.3 | 1.8 | ±0.4 | 1.6 | ±0.4 | 1.3 | ±0.2 | 2.2 | ±0.4 | 1.43 | ±0.03 |
| Basophils | 0.13 | ±0.04 | 0.20 | ±0.06 | 0.20 | ±0.03 | 0.10 | ±0.02 | 0.10 | ±0.02 | 0.17 | ±0.12 |
| Coagulation panel | ||||||||||||
| Platelet count (103/μl) | 544 | ±120 | 532 | ±183 | 473 | ±72 | 355 | ±105 | 576 | ±89 | 291 | ±226 |
| Prothrombin time (s) | 18.2 | ±2.4 | 23.5 | ±8.0 | 22.2 | ±4.1 | 20.6 | ±0.1 | 14.3 | ±0.2 | 32.8 | ±17.5 |
| Partial thromboplastin time (s) | 52 | ±4 | 51 | ±4 | 47 | ±3 | 50 | ±1 | 55 | ±2 | 55 | ±9 |
*
p < 0.05 with respect to the control group. N = 3–6 animals per group. Bold denotes statistical significance.