Table 3.
Clinical Chemistry Panel for Targeted S-Nitrosyl Nanofiber
| Targeted SNO nanofiber | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Control group | 3 h | Day 1 | Day 2 | Day 3 | Day 7 | |||||||
| Mean | SEM | Mean | SEM | Mean | SEM | Mean | SEM | Mean | SEM | Mean | SEM | |
| Alkaline phosphatase (U/L) | 185 | ±19 | 153 | ±13 | 229 | ±20 | 196 | ±31 | 144 | ±8 | 203 | ±15 |
| Alanine transaminase (U/L) | 94 | ±13 | 58* | ±2 | 58* | ±6 | 48* | ±3 | 42* | ±5 | 51* | ±3 |
| Aspartate transaminase (U/L) | 145 | ±27 | 162 | ±31 | 98 | ±15 | 64 | ±5 | 54 | ±5 | 69 | ±9 |
| Creatine kinase (U/L) | 565 | ±118 | 452* | ±44 | 175 | ±12 | 231 | ±36 | 145 | ±2 | 237 | ±67 |
| Total protein (g/dl) | 5.5 | ±0.1 | 4.9 | ±0.1 | 5.7 | ±0.1 | 5.4 | ±0.1 | 5.7 | ±0.1 | 5.5 | ±0.1 |
| Albumin (g/dl) | 2.9 | ±0.1 | 2.6 | ±0.1 | 2.9 | ±0.0 | 2.8 | ±0.0 | 2.9 | ±0.1 | 2.8 | ±0.1 |
| Globulin (g/dl) | 2.6 | ±0.1 | 2.3 | ±0.1 | 2.8 | ±0.1 | 2.6 | ±0.1 | 2.8 | ±0.1 | 2.7 | ±0.1 |
| Blood urea nitrogen (mg/dl) | 18 | ±1 | 33.5* | ±1.5 | 21.8 | ±1.1 | 17.0 | ±1.7 | 19.7 | ±0.7 | 23.3 | ±2.4 |
| Creatinine (mg/dl) | 0.38 | ±0.02 | 0.7 | ±0.1 | 0.4 | ±0.0 | 0.4 | ±0.0 | 0.4 | ±0.0 | 0.4 | ±0.0 |
| Cholesterol (mg/dl) | 86.5 | ±4.5 | 67.2 | ±1.7 | 85.5 | ±2.5 | 95.3 | ±5.7 | 91.7 | ±2.7 | 78.7 | ±0.3 |
| Glucose (mg/dl) | 259 | ±17 | 413* | ±29 | 250 | ±9 | 256 | ±9 | 275 | ±7 | 297 | ±25 |
| Phosphate (mg/dl) | 7.3 | ±0.2 | 10.2 | ±0.9 | 7.9 | ±0.1 | 7.4 | ±0.1 | 7.4 | ±0.2 | 8.4 | ±0.9 |
| Bicarbonate (mmol/L) | 25.8 | ±0.5 | 19 | ±1 | 24 | ±1 | 24.3 | ±0.3 | 23 | ±0.6 | 25 | ±1 |
| Sodium (mmol/L) | 142.0 | ±0.4 | 137.8 | ±1.2 | 142.3 | ±0.3 | 141.0 | ±0.3 | 140.7 | ±0.6 | 140.3 | ±1.3 |
| Potassium (mmol/L) | 4.6 | ±0.1 | 5.7 | ±0.2 | 5.2 | ±0.1 | 5.2 | ±0.1 | 5.2 | ±0.1 | 5.2 | ±0.3 |
*
p < 0.05 with respect to the control group. N = 3–6 animals per group. Bold denotes statistical significance.