Table 4.
Clinical Chemistry Panel for Targeted SH Nanofiber
| Targeted SH nanofiber | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Control group | 3 h | Day 1 | Day 2 | Day 3 | Day 7 | |||||||
| Mean | SEM | Mean | SEM | Mean | SEM | Mean | SEM | Mean | SEM | Mean | SEM | |
| Alkaline phosphatase (U/L) | 185 | ±19 | 162 | ±10 | 154 | ±17 | 183 | ±7 | 179 | ±12 | 180 | ±12 |
| Alanine transaminase (U/L) | 94 | ±13 | 177 | ±128 | 117 | ±51 | 61 | ±4 | 46 | ±3 | 72 | ±3 |
| Aspartate transaminase (U/L) | 145 | ±27 | 287 | ±135 | 164 | ±67 | 73 | ±6 | 75 | ±8 | 96 | ±7 |
| Creatine kinase (U/L) | 565 | ±118 | 2412* | ±1517 | 335 | ±34 | 251 | ±46 | 294 | ±81 | 378 | ±58 |
| Total protein (g/dl) | 5.5 | ±0.1 | 4.9 | ±0.2 | 5.4 | ±0.1 | 5.5 | ±0.1 | 5.6 | ±0.1 | 5.7 | ±0.1 |
| Albumin (g/dl) | 2.9 | ±0.1 | 2.5 | ±0.1 | 2.9 | ±0.1 | 2.9 | ±0.1 | 3.0 | ±0.1 | 2.9 | ±0.0 |
| Globulin (g/dl) | 2.6 | ±0.1 | 2.4 | ±0.1 | 2.5 | ±0.1 | 2.6 | ±0.1 | 2.7 | ±0.1 | 2.9 | ±0.1 |
| Blood urea nitrogen (mg/dl) | 18 | ±1 | 37* | ±2 | 21 | ±2 | 19 | ±1 | 20 | ±1 | 20 | ±1 |
| Creatinine (mg/dl) | 0.38 | ±0.02 | 1.02 | ±0.18 | 0.40 | ±0.02 | 0.40 | ±0.02 | 0.40 | ±0.02 | 0.40 | ±0.00 |
| Cholesterol (mg/dl) | 86.5 | ±4.5 | 70 | ±8 | 81 | ±3 | 85 | ±3 | 97 | ±3 | 87.3 | ±0.9 |
| Glucose (mg/dl) | 259 | ±17 | 509* | ±112 | 244 | ±24 | 283 | ±36 | 257 | ±31 | 272 | ±13 |
| Phosphate (mg/dl) | 7.3 | ±0.2 | 14.2 | ±4.9 | 6.6 | ±0.6 | 7.0 | ±0.4 | 7.4 | ±0.2 | 7.5 | ±0.1 |
| Bicarbonate (mmol/L) | 25.8 | ±0.5 | 17.4 | ±5.3 | 26.5 | ±0.7 | 27.3 | ±0.3 | 28.0 | ±0.4 | 24.7 | ±0.3 |
| Sodium (mmol/L) | 142.0 | ±0.4 | 139.0 | ±1.9 | 140.3 | ±0.8 | 140.7 | ±0.6 | 141.7 | ±0.8 | 142.3 | ±0.3 |
| Potassium (mmol/L) | 4.6 | ±0.1 | 6.3 | ±0.3 | 4.7 | ±0.3 | 4.7 | ±4.5 | 0.2 | ±12 | 4.6 | ±0.2 |
*
p < 0.05 with respect to the control group. N = 3–6 animals per group.