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. 2016 Mar 8;10:19. doi: 10.3389/fnsys.2016.00019

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Copyright © 2016 Murugan, Santhakumar and Kannurpatti.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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fLDI somatosensory (S1_BF) activation in mTBI animals after vehicle or kaempferol treatment. (A,D) Baseline fLDI flux in the vehicle and kaempferol-treated animals respectively, indicating baseline CBF decrease in the S1_BF region on the injured (ipsilateral) side (arrows). (B,E) Whisker deflection-induced functional activation indicating CBF changes overlaid on the baseline image. A reduced functional asymmetry is evident after kaempferol treatment. (C,F) Activation area of positive and negative CBF responses at the group level represented as Mean ± SD. Vehicle group; n = 3, kaempferol group; n = 6. Significance tested using one-way ANOVA, Post-hoc Tukey's HSD test. Scale bar = 1 mm, R, right; L, left; Ipsi, ipsilateral; Con, contralateral; cc, correlation coefficient; rpu, relative perfusion units.