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(a) Phylogenetic tree of the PRD family including human envoplakin, desmoplakin, BPAG1e, BPAG1b, MACF1b, plectin and epiplakin, as generated by ClustalW. PRD modules are grouped into four subtypes, including a new PRD-D subtype. (b) Domain organization of the human plakin proteins with their PRD subtype and additional modules indicated. Note that BPAG1b and BPAG1e are encoded by the dystonin gene.
