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. 2016 Mar 8;6:22635. doi: 10.1038/srep22635

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Copyright © 2016, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(A) Integrated regulatory network constructed using Cytoscape. The network includes two types of nodes: differentially expressed proteins identified from protein profiling (pink squares), and their interaction targets (blue squares) derived from six publically available databases. (B) Node degree distribution of differentially expressed proteins. (C) Cluster analysis ranking of the top hits in the B12 regulatory network using the cluster search algorithm MCODE.