Table I.

Haematological data in study subjects.

Assay	AA (n = 22)	AS (n = 17)	SS (n = 16)	P-value*		P-value†
WBC (×109/l)	6.1 (5.0–7.4)	6.8 (5.8–7.1)	8.8 (6.7–12.4)		0.5422	0.0105
AMC (×109/l)	0.3 (0.3–0.4)	0.4 (0.3–0.5)	0.6 (0.4–0.8)		0.0600	0.0023
ANC (×109/l)	3.3 (2.2–4.0)	4.1 (3.2–4.4)	4.1 (3.2–6.0)		0.1563	0.0397
Platelet count (×109/l)	285 (255–327)	325 (290–364)	399 (308–512)		0.0474	0.0052
Hb (g/l)	125 (121, 131)	124 (120–137)	86 (82–100)		0.7984	<0.0001
LDH (iu/l)	463 (436–525)	518 (454–558)	1022 (905–1144)		0.2549	<0.0001
Haptoglobin (mg/l)
<220	0 (0%)	2 (12%)	14 (93%)		0.0553	<0.0001
220–1390	10 (45%)	11 (65%)	1 (7%)
>1390	12 (55%)	4 (24%)	0 (0%)

Data are presented as median (interquartile range) or n (%).

AA, HbAA individuals (controls); AS, HbAS individuals (sickle cell trait); SS, HbSS individuals (sickle cell disease); WBC, white blood cell count; Hb, haemoglobin concentration; LDH, lactate dehydrogenase; ANC, absolute neutrophil count; AMC, absolute monocyte count.

^*Comparison of AA to AS.

^†Comparison of AA to SS.