Skip to main content
. Author manuscript; available in PMC: 2016 Mar 8.
Published in final edited form as: Br J Haematol. 2015 Sep 7;171(4):638–646. doi: 10.1111/bjh.13641

Table III.

Thrombin generation and plasma clot formation parameters.

Parameter AA (n = 21) AS (n = 16) SS (n = 17) P-value* P-value†
Thrombin generation
 Lag time (min)       5.3 (4.8–6.3)       5.2 (4.7–5.7)       5.1 (4.2–5.5) 0.4433   0.1052
 Time to peak (min)       9.9 (9.2–10.7)     10.4 (9.2–11.4)       8.1 (7.7–9.1) 0.6693   0.0001
 Thrombin peak (nmol/l)   163.6 (128.8–206.6)   168.3 (130.6–233.1)   203.2 (173.1–232.8) 0.6826   0.0887
 ETP (nmol/l × min) 1496.0 (1431.5–1770.8) 1623.4 (1395.1–1851.5) 1217.5 (1170.0–1329.5) 0.4573 <0.0001
Clotting
 Onset (min)     15.0 (12.0–16.5)     12.3 (10.4–15.4)     11.6 (8.9–14.8) 0.2802   0.0418
 Rate (mOD/min)     78.6 (52.4–99.3)     60.8 (40.7–83.7)     83.8 (55.4–120.9) 0.2060   0.2943
 Change in turbidity     0.70 (0.57–0.78)     0.68 (0.61–0.76)     0.67 (0.56–0.77) 0.9638   0.7277

Data are presented as median (IQR).

AA, HbAA individuals (controls); AS, HbAS individuals (sickle cell trait); SS, HbSS individuals (sickle cell disease); ETP, endogenous thrombin potential; mOD, mean optical density.

*

Comparison of AA to AS.

†

Comparison of AA to SS.