Table 2. Serum CRP, IL-6 and GM-CSF levels in advanced pancreatic cancer patients pre- and post-chemotherapy treatment and radiological response (n=38).
|
CRP (mg l−1) |
CRP |
IL-6 (pg ml−1) |
IL-6 |
GM-CSF (pg ml−1) |
GM-CSF | ||||
|---|---|---|---|---|---|---|---|---|---|
| Radiological response | Pre | Post | % Change | Pre | Post | % Change | Pre | Post | % Change |
| PD | 6 | 38 | 533.33 | 23.52 | 33.07 | 40.6 | 0 | 0 | 0 |
| PD | 27 | 16 | −40.74 | 25.59 | 14.98 | −41.46 | 0 | 0 | 0 |
| PD | 5 | 5 | 0 | 20.98 | 21.91 | 4.43 | 0 | 0 | 0 |
| PD | 38 | 31 | −18.42 | 22.88 | 56.91 | 148.73 | 0 | 0 | 0 |
| PD | 60 | 48 | −20 | 10.52 | 13.95 | 32.6 | 0 | 0 | 0 |
| PD | 8 | 11 | 37.5 | 36.53 | 17.91 | −50.97 | 4.51 | 0 | −100 |
| PD | 16 | 5 | −68.75 | 21.15 | 7.96 | −62.36 | 72.43 | 34.12 | −52.89 |
| PD | 5 | 24 | 380 | 30.49 | 50.11 | 64.35 | 0 | 34.96 | 0 |
| PD | 238 | 175 | −26.47 | 34.19 | 33.27 | −2.69 | 0 | 0 | 0 |
| PR | 8 | 25 | 212.5 | 9.44 | 2.88 | −69.49 | 0 | 0 | 0 |
| SD | 5 | 20 | 300 | 28.91 | 19.03 | −34.18 | 0 | 0 | 0 |
| SD | 11 | 7 | −36.36 | 23.84 | 22.63 | −5.08 | 0 | 51.61 | 100 |
| SD | 5 | 9 | 80 | 41.9 | 23.39 | −44.18 | 0 | 0 | 0 |
| SD | 5 | 5 | 0 | 20.06 | 17.87 | −10.92 | 0 | 0 | 0 |
| SD | 7 | 60 | 757.14 | 37.56 | 57.93 | 54.23 | 0 | 0 | 0 |
| SD | 7 | 27 | 285.71 | 21.56 | 403.25 | 1770.36 | 0 | 0 | 0 |
| SD | 34 | 21 | −38.24 | 1163.43 | 914.06 | −21.43 | 549.41 | 426.57 | −22.36 |
| SD | 5 | 10 | 100 | 9.49 | 13.05 | 37.51 | 2.88 | 0 | −100 |
| SD | 13 | 29 | 123.08 | 36.55 | 17.85 | −51.16 | 30.4 | 0 | −100 |
| SD | 5 | 17 | 240 | 35.82 | 50.34 | 40.54 | 0 | 0 | 0 |
| SD | 10 | 8 | −20 | 24.17 | 20.11 | −16.8 | 0 | 0 | 0 |
| SD | 25 | 6 | −76 | 29.31 | 11.81 | −59.71 | 0 | 0 | 0 |
| SD | 92 | 37 | −59.78 | 49.65 | 24.72 | −50.21 | 0 | 0 | 0 |
| SD | 5 | 5 | 0 | 10.12 | 10.28 | 1.58 | 0 | 0 | 0 |
| SD | 5 | 5 | 0 | 50.89 | 125.54 | 146.69 | 0 | 109.01 | 0 |
| SD | 5 | 5 | 0 | 10.28 | 15.74 | 53.11 | 0 | 0 | 0 |
| SD | 41 | 5 | −87.8 | 19.63 | 12.29 | −37.39 | 0 | 0 | 0 |
| SD | 27 | 33 | 22.22 | 24.3 | 38.6 | 58.85 | 0 | 0 | 0 |
| SD | 5 | 5 | 0 | 20.39 | 12.45 | −38.94 | 0 | 0 | 0 |
| SD | 13 | 13 | 0 | 24.91 | 12.61 | −49.38 | 11.08 | 2.41 | −78.25 |
| SD | 6 | 9 | 50 | 10.73 | 14.38 | 34.02 | 0 | 0 | 0 |
| SD | 5 | 28 | 460 | 14.01 | 19.4 | 38.47 | 6.28 | 10.27 | 63.54 |
| SD | 5 | 5 | 0 | 21.08 | 19.73 | −6.4 | 24.34 | 7.92 | −67.46 |
| SD | 11 | 10 | −9.09 | 19.4 | 7.23 | −62.73 | 1.68 | 0.28 | −83.33 |
| SD | 5 | 5 | 0 | 22.9 | 11.4 | −50.22 | 0 | 0 | 0 |
| SD | 5 | 26 | 420 | 15.36 | 17.75 | 15.56 | 0 | 17.73 | 0 |
| SD | 9 | 5 | −44.44 | 23.45 | 18.71 | −20.21 | 0 | 0 | 0 |
| SD | 5 | 5 | 0 | 14.09 | 9.37 | −33.5 | 0 | 0 | 0 |
| PD median (IQR) | 16 (5.5 to 49) | 24 (8 to 43) | −18.4 (−33.6 to 209) | 23.5 (21 to 32.3) | 21.9 (14.5 to 41.7) | 4.4 (−46 to 52.5) | Yes=2 No=7 | Yes=2 No=7 | Yes=2 No=7 |
| SD median (IQR) | 5.5 (5 to 12) | 9 (5 to 23.5) | 0 (−14.5 to 111) | 23.2 (17.4 to 32.6) | 18.3 (12.5 to 24.1) | −13.9 (−41.6 to 38) | Yes=7 No=21 | Yes=8 No=20 | Yes=8 No=20 |
| All median (IQR) | 7 (5 to 16) | 10.5 (5 to 27) | 0 (−20 to 123) | 23.2 (19.4 to 30.4) | 18.3 (12.6 to 33.1) | −8.66 (−8.7 to 38.5) | Yes=9 No=29 | Yes=10 No=28 | Yes=10 No=28 |
Abbreviations: CRP=C-reactive protein; GM-CSF=granulocyte macrophage-colony-stimulating factor; IL-6=interleukin 6; IQR=interquartile range; PD=progressive disease; PR=partial response; SD=stable disease.